Tranquilene Reviews


Ingredients 5.5
Safety 4.0
Price 6.5
Dosage 4.5


  • Contains some good ingredients


  • Proprietary Blends
  • Potential Side Effects from GABA

Read on to see our full Tranquilene review.

What is Tranquilene Total Calm?

Tranquilene Total Calm by Tranquility Labs is a stress and anxiety supplement which is claimed to promote:

  • Anxiety Relief

  • Mood Boosts

  • Restore Mental Balance

But how effective is it really?

In this Tranquilene review, we look closer at this supplement to see how effective it really is. This is what you need to know…

Tranquilene Ingredients

Below is the Tranquilene ingredients list:

  • Passion Flower

  • GABA

  • L-Tryptophan

  • Ashwagandha

  • Bacopa Monnieri

  • L-Theanine

  • Green Tea Extract

Tranquilene Ingredients

These all ingredients which can help to some extent with stress and anxiety. However, they are all part of a proprietary blend.

A proprietary blend is a combination of more than one ingredient under a single dosage. The problem with this is that you have no idea how much of each ingredient, nor how effective it may be overall in the supplement.

Below, we look closer at the ingredients in Tranquilene to see how effective it really is.

This is what you need to know…

Passion Flower

The Passion Flower is in the Buttercup family. It is a perennial and likes to grow in sun to partial shade. The flowers are a very light, soft pink that grows on an erect plant that can grow up to 3 feet tall with lush green leaves.

The Passion Flower can be used for some different things, as it has many medicinal uses that have been passed down for centuries. Some people use the flower to soothe and calm their nerves, while others use it as an anti-depressant or even a sedative. The Passion Flower has also been found useful for treating headaches, sleep disorders and inflammation of the joints among other conditions.

Passion flower is a popular plant thanks to its calming and sedative effects. The soothing effect of the flowers is mainly due to the apigenin within them. Apigenin helps to reduce feelings of stress and anxiety by acting on serotonin receptors in the brain. It also has anti-inflammatory properties that help it to relieve symptoms of rheumatoid arthritis and other inflammatory conditions.


GABA stands for gamma-aminobutyric acid. It is an amino acid that is found in the brain and other parts of the central nervous system, including the spinal cord.

It is one of the most common inhibitory neurotransmitters in the brain and regulates a number of essential functions in humans such as sleep, mood, memory and cognitive function. GABA is also thought to play a role in depression, anxiety disorders and seizures.


L-Tryptophan is an amino acid that is primarily used for the production of serotonin.

L-tryptophan is an essential amino acid for humans and is classified among the eight essential amino acids because it cannot be produced by the human body. It can be found in high levels in some foods, including milk, eggs, cheese, red meat, green peas, oats and soybeans.

The production of serotonin from L-tryptophan relies on other amino acids like phenylalanine and tryptophan hydroxylase enzyme.

L-Tryptophan also plays an important role in immunity as it can be converted into kynurenine which blocks inflammation to reduce swelling.


Ashwagandha is one of the most powerful herbs that you can use to boost your immune system and lower the risk of getting sick. Not only does it help boost your immune system, but it also helps improve your sleep, lowers stress levels and boosts the production of testosterone in men.

The mainstream name for Ashwagandha is Indian ginseng because it grows in India and has similar effects to that as well.

The term Ashwagandha translates to “smell of horse”, which refers to the smell of the dried leaves of the plant that was likened to a horse’s sweat. It is often described as being a pungent smell and it can often result in headaches when too much is consumed at once.

Bacopa Monnieri

Bacopa Monnieri is a plant that is found in India. It has been used for centuries to treat amnesia, epilepsy, asthma and edema.

Bacopa Monnieri is an herb traditionally used by Ayurvedic medicine for many ailments such as amnesia, epilepsy, asthma and edema. It has been used for centuries in Asia as an all-purpose cure. For these reasons, it is often thought of as a “wonder drug”.

Some studies have shown that Bacopa Monnieri may help with depression and anxiety disorders. Some people take it to improve their memory or concentration level or for weight loss purposes.

There are also some possible side effects of taking this supplement including dry mouth, stomach discomfort and insomnia.


L-theanine is an amino acid that is found in green tea and has a calming effect on the body.

The main theory behind how L-theanine works is that it binds to the alpha brainwave receptors, which in turn alters your mood from stressed to calm. This type of brainwave can be described as relaxed and alert at the same time.

L-theanine is an amino acid that is naturally found in green tea. It functions as a natural sedative which can help with improving sleep quality and duration.

L-theanine is able to cross the blood-brain barrier and interact with glutamate receptors in the brain to produce a calming effect without causing drowsiness or other side effects commonly associated with prescription drugs. L-theanine has neuroprotective properties that can help slow cognitive decline, reduce the risk of developing Alzheimer’s disease, and improve long term memory.

Green Tea Extract

Green tea is a beverage that is made from the leaves of the Camellia sinensis plant. In addition to tasting great, it also has many health benefits.

It’s considered to be a healthy drink because it contains polyphenols which can help prevent cancer and heart disease. Additionally, green tea also contains caffeine which can help reduce stress levels and boost mental alertness.

The caffeine content in two cups of green tea is about half the amount found in one cup of coffee, but it still has enough to energize you without causing an unhealthy spike in your blood sugar levels.

Tranquilene Side Effects

Tranquilene Total Calm Side Effects

Tranquilene is unlikely to cause side effects. However, there is always some potential for risk, the main risk in this case comes from the GABA in this supplement.

GABA (gamma-aminobutyric acid) is a neurotransmitter that is responsible for inhibiting brain activity. It is made from glutamate and glutamine. When GABA levels are high, the neuron will be less likely to fire an action potential. This results in relaxation, slowing of the heart rate and lowering blood pressure.

Side effects of taking too much GABA can include:

  • Drowsiness

  • Lethargy

  • Mental sluggishness

  • Dizziness

This is not ideal when you’re looking for a supplement to help relax you and alleviate stress.

Tranquilene Drug Interactions

Tranquilene is unlikely to interact with any drugs that you may be taking. It’s all completely natural, so shouldn’t cause any issues with any prescription you may be taking.

However, we would be wary of the GABA as this shouldn’t be taken with alcohol, as the two can worsen the effect of one another. We would advise not drinking with Tranquilene.

In addition, if you are on some form of medication, we strongly suggest talking to your doctor before taking a supplement like Tranquilene alongside it.

Tranquilene VS Xanax

Tranquilene and Xanax are very different products. Tranquilene is a natural anxiety management supplement, and Xanax is a prescription drug prescribed to help reduce anxiety.

One is natural and one is synthetic.

Xanax is a benzodiazepine and anxiety medication.

Xanax, also known as Alprazolam, is a medication used to treat anxiety. It can also be used for other uses such as panic disorders and sleep problems. In the United States, it has been prescribed for about 30 million people each year as of 2017.

The drug works by stimulating the GABA receptors in the brain which reduces feelings of anxiety. This effect usually lasts from six to eight hours after taking the drug depending on whether it is taken as a single dose or split into two doses per day. It should not be mixed with alcohol or other sedatives because this can result in an overdose and death.

Tranquilene is a completely natural supplement. The effects aren’t as potent as Xanax, but the risk and side effects associated with it are greatly diminished.

You should only use Xanax if you are prescribed it by your doctor. This medication can be addictive so it is important not to take Xanax for more than the prescribed time period.

Tranquilene Total Calm

How long does it take for Tranquilene to work?

Tranquilene’s short term effects can take anywhere from 30 – 60 minutes to work. For longer term effects, regular use of Tranquilene for 2 – 4 weeks should yield greater effects.

Ideally you should be using Tranquilene on a regular basis to get the full effects of this natural supplement.

Is Tranquilene FDA approved?

Tranquilene is not FDA approved. The FDA does not approve natural supplements as they do not fall into their scope of what they can and can’t approve.

The FDA can’t approve supplements. They just approve drugs and devices.

The Food and Drug Administration (FDA) is an agency of the United States Department of Health and Human Services (HHS). The FDA “is responsible for protecting the public health by assuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation’s food supply, cosmetics, and products that emit radiation.”

The FDA does not approve supplements. They only regulate drugs and devices in the form of a prescription or over-the-counter medicine.

This means Tranquilene cannot be approved by the FDA.

Tranquilene Reviews

Tranquilene Total Calm Review Summary

Tranquilene Total Calm is a natural stress and anxiety supplement. However, from our Tranquilene review, we can reveal that we do not believe it to be the best on the market.

One of the main drawbacks here is that the ingredients in Tranquilene (the active ingredients anyway) are part of a proprietary blend. You don’t know how much of each ingredient you’re getting or how effective it really is overall.

Not only that, ingredients in Tranquilene like GABA can lead to side effects if used with alcohol or taken too often. There’s just a lot that could cause problems in this supplement when compared to some other options on the market.

There are better options out there if you do your research.

Our Current #1 Anxiety Supplement:
SRS Stress Relief

SRS Nutra has formulated what we believe to be the most effective stress relief on the market today.

This supplement is the best for:

  • Promoting Calmness
  • Lessening Anxiety
  • Promoting Sleep

It's also been endorsed by several doctors. You can read our full review or visit their site below:

Our Review

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