OmegaXL Review: Ingredients, Side Effects, Pros and Cons

OmegaXL Review: Ingredients, Side Effects, Pros and Cons. Omega XL has been proven to provide significant weight loss benefits without requiring a special diet or exercise regimen. The only catch is that you need to take it for at least 90 days in order to see results.

OmegaXL is a supplement that claims to help with weight loss, energy levels and more. It also has some side effects including nausea and headaches. Read more in detail here: what are the side effects of taking omega xl.


  • DHA and EPA dosages that are enough
  • Omega-3 fats have a lot of evidence suggesting they’re good for joint health and inflammation.
  • There is no aftertaste of fish.
  • Capsules that are convenient and simple to consume


  • There is no information on the specific quantities of ingredients used in this product.
  • There is no third-party testing and certification mark on it.
  • High-priced

What Is OmegaXL and How Does It Work?

OmegaXL is an omega-3 supplement that claims to relieve joint pain, muscular tightness, and inflammation.

It’s a substitute for fish oil. A patented mix of 30 fatty acids, including DHA and EPA, is said to be included in the recipe.

Green-lipped mussels from sustainable mussel farms off the coast of New Zealand are used instead of fish, krill, or algae in this formulation.

OmegaXL comprises the omega-rich oil combination indicated above, as well as pharmaceutical-grade Vitamin E with Olive Oil. (an antioxidant often used to prevent rancidity).


What Exactly Is Omega-3?

OmegaXL is a powerful fatty acid combination that contains DHA and EPA. OmegaXL has upwards of 30 fatty acids, when most fish oils only comprise two, according to the company.

Unsaturated fatty acids are divided into two categories: omega-3s and omega-6s. Omega-3s are structural components of the phospholipids that make up cell membranes and may be found in every cell, notably in the brain and eyes.

Eicosanoids, signaling molecules that act in the immunological, endocrine, pulmonary, and cardiovascular systems, are also made using them.

While fish and shellfish are the finest dietary sources of EPA and DHA, many Western cultures don’t consume enough of them, thus a supplement may be advantageous.

OmegaXL claims to be a more powerful fatty acid source than fish oil.

As a trained dietitian, my first reservation regarding OmegaXL concerns the allegedly large quantity of fatty acids utilized.

Alpha-linolenic acid (ALA, an omega-3 fatty acid) and linoleic acid are the only two necessary fatty acids (an omega-6 fatty acid). These two fats are enough to create all of the other fats the body requires.

While supplementing with DHA and EPA is standard, I’m not sure why OmegaXL includes so many additional fatty acids without explanation.

Ingredients Evaluation

The advantages of EPA and DHA are backed up by a large body of research.

This includes their ability to improve joint health by lowering pro-inflammatory mediators and enhancing joint lubrication via anti-inflammatory actions.

Many studies have shown that omega-3 may help relieve the symptoms of osteoarthritis.

According to certain studies, omega-3s have a pain-relieving effect equivalent to ibuprofen or NSAIDs for nonsurgical pain.

There are no links on the website to “30+ years of published study on the unique oil combination,” which refers to their proprietary extract.

Furthermore, although there are several redirection to the sales page, the product website lacks a supplement facts label.

In the FAQ section, the question “What are the components in OmegaXL?” is answered, however the response does not specify how much of each ingredient is present.

When I go to the Amazon page for the product, I can see a picture of the supplement facts label, which lists all of the components under “OmegaXL Proprietary Blend” and in a single dose of 300 mg.

Below is a discussion of the studies I discovered on joints and Extract of the Green-Lipped Mussel, the major source of omega-3 utilized in OmegaXL.

Extract of the Green-Lipped Mussel

A green-lipped mussel (GLM) enriched diet was administered to 23 dogs with osteoarthritis for 60 days after a 30-day control diet in a 2013 animal trial.

Throughout the trial, plasma omega-3 fatty acid concentrations were monitored, and gait and motor function were assessed.

The scientists observed that the GLM-enhanced food resulted in better gait and motor performance in the dogs, as well as a reduction in several baseline symptoms.

In another trial, 81 dogs with mild to severe degenerative joint disease were given a placebo or GLM extract for 56 days in addition to their usual food.

While one veterinarian performed exams, their owners provided subjective ratings of clinical joint complaints.

GLM-treated dogs showed better musculoskeletal scores on day 56. By day 112, however, the effects of GLM were identical to those of the placebo group.

GLM seems to help lessen arthritic joint pain in the short term, but additional research into long-term treatment is required.

Researchers evaluated the effects of high-dose GLM extract on symptoms of osteoarthritis of the knee in a human trial conducted in 2012.

Twenty-one patients with knee osteoarthritis were given a daily dosage of 3,000 mg GLM for eight weeks. GLM dramatically relieved joint discomfort, stiffness, and mobility, according to the researchers.

In another 2013 human trial, researchers found that Extract of the Green-Lipped Mussel was more effective than fish oil in alleviating osteoarthritis-related joint pain over 12 weeks.

This includes an 89 percent reduction in pain symptoms and a 91 percent improvement in quality of life.

In a 2017 research, fish and krill oils were shown to be superior than GLM in protecting dogs against collagen breakdown and to be more promising for cartilage protection.

Overall, the available scientific support for using Extract of the Green-Lipped Mussel for joint relief in humans is limited. More research is needed.

Furthermore, the medication “has been proved in clinical studies to enhance joint health, mobility, and muscle rehabilitation,” according to the brand’s website.

However, the only clinical research I could locate on this substance was a trial of 20 persons with asthma that found it to aid with hyperpnea-induced bronchoconstriction.

Omega-3 supplements, in general, are beneficial for muscular discomfort. In the case of green-lipped mussels, a few modest human trials have shown possible advantages. 

For instance, in a 2020 study, 51 untrained men were given 600 mg per day of either Extract of the Green-Lipped Mussel (GLM) or a combination of 75% GLM with 25% krill oil for 26 days prior to and 72 hours following downhill running exercise.

When compared to placebo, both were shown to help minimize the onset of muscular soreness. 

A 2013 study among 32 distance runners, using the same Extract of the Green-Lipped Mussel supplement, found that 400 mg per day of GLM for 11 weeks was effective for preventing muscle soreness onset after a 30 km distance run among men and women, compared to an olive oil placebo. The benefits were more significant for lesser trained runners.

In a 2015 trial, 32 untrained males were given 1,200 mg per day for 26 days before downhill running and continued for 96 hours thereafter, and the GLM was shown to be more effective than a placebo in decreasing muscle damage and inflammation following muscle-damaging activity.


Extract of the Green-Lipped Mussel effectively reduced joint pain in dogs and was shown beneficial in a small human study. Some smaller human studies have also demonstrated its ability to help alleviate the onset of muscle soreness after exercise. But, unfortunately, this isn’t enough evidence to convince me that it’s necessarily a better omega-3 source for people than what’s currently on the market.

Vitamin E with Olive Oil

The product website FAQ section states that this product also contains pharmaceutical-grade Vitamin E with Olive Oil. 

Overall, the use of olive oil for joint pain varies, and the results of additional olive oil are mixed.

Many research have looked at the anti-inflammatory benefits of include olive oil in one’s diet and using it topically.

Combining olive oil supplementation with fish oil may provide more substantial joint pain alleviation, according to a 2005 clinical investigation.

Participants with osteoarthritis have been widely examined when it comes to vitamin E. However, the majority of the evidence provided tends to yield mixed outcomes.


Solid scientific evidence for using Vitamin E with Olive Oil for joint pain is lacking. In addition, the exact amounts of these ingredients in OmegaXL formulation are not provided by the company, so it’s difficult to make statements about their potential benefit. 

Conclusion on Benefits Claimed

Based on the existing studies, we’ve compiled a summary of the available evidence regarding OmegaXL’s stated benefits:

It helps to relieve joint pain. Evidence of Moderate Strength
Inflammation is reduced. Evidence of Moderate Strength
It aids in the relief of muscular aches and pains. Evidence of Moderate Strength

While Extract of the Green-Lipped Mussel is rich in omega-3 fats that have documented benefits, there is only Evidence of Moderate Strength available on the benefits of this extract specifically for joints and inflammation, as well as its ability to improve muscle soreness.


Safety, Dosage, and Side Effects

For the first eight weeks, OmegaXL capsules should be taken with meals. This, I suppose, is to reduce the possibility of intestinal pain, which is often mentioned in supplement warnings.

OmegaXL includes molluscan shellfish oil, which may cause allergic reactions. It promises to eliminate allergenic proteins using a patented extraction method.

While there is no worry about vitamin E toxicity from food, excessive dosages of supplementary vitamin E may cause blood thinning and increase the risk of stroke.

Blood-thinning drugs, as well as the breast cancer therapy tamoxifen and the immunosuppressant drug cyclosporine, may be affected.

There is no information on how much vitamin E is in this product. 

A 2013 trial among humans using Extract of the Green-Lipped Mussel for osteoarthritis concluded that this substance had no side effects for participants.

However, several studies have linked toxins in mussels used in some brands of these items to liver inflammation.

While some patients have complained of slight nausea, upset stomach, and fluid retention, newer studies have identified no severe adverse effects in participants.

Overall, it’s advisable to see a doctor before taking this product, particularly if you have an allergy, are pregnant, nursing, routinely use drugs, or have a medical condition.

Where to Buy and How Much

OmegaXL comes in a bottle with 60 softgels. One bottle lasts two weeks at a recommended dosage of four capsules each day, and costs $39.95 per bottle or roughly $80.00 for a month.

However, when you make your first purchase, you will get a free bonus item.

You may also join up for an auto-ship service, which will send you two 60-count bottles every month for $69.98 plus $4.95 delivery.

The OmegaXL supplement is backed by a 60-day money-back guarantee.

You may buy straight from the brand’s website or via their Amazon shop.

However, the greatest deal may be found on the brand’s website, since it looks that even Amazon’s Subscribe-and-Save option costs close to $100.00 every month.

How OmegaXL Measures Up to the Competition

Fish, krill, and algae are used in most omega-3 supplements, however green-lipped mussels are included in a handful.

OmegaXL costs $1.32 a day, which looks to be at the top end of a wide range of similar product pricing.

Turner New Zealand Green-Lipped Mussel Oil is a comparable product that costs $29.99 for 60 capsules or A similar product is Turner New Zealand Green-Lipped Mussel Oil, priced at $29.99 for 60 capsules or a one-month supply for $0.50 per day..50 per day for a month’s supply.

This product, like OmegaXL, classifies everything under a proprietary mix, but it also includes flax, hemp, kiwifruit, grape seed, and blackcurrant seed oils and extracts, as well as astaxanthin. It’s rich in antioxidants and carotenoids, according to the label. 

A product named FREZZOR Omega 3 Black – Green Lipped Mussel Oil is quite similar to the Turner offering.

It has the same components as the original, including a 120 mg blend of green-lipped mussel, flax, grape seed, and kiwifruit oils.

This is perhaps the most costly of them, with two 60-count bottles costing $93.99, or $1.50 each day.

HakaLife GLX3 Green-Lipped Mussel Oil is another rival. For $59.99, or Another competitor is HakaLife GLX3 Green-Lipped Mussel Oil. New customers can buy one 60-capsule bottle and get a second one free, for a price of $59.99 or $0.99 per day..99 a day, new customers can purchase one 60-capsule bottle and get a second one for free.

According to the manufacturer, each 2-capsule daily dosing includes 100 mg of green-lipped mussel oil. Vitamin E, olive oil, and a unique combination are also included.


All of the items listed above have a comparable high price, little information about their components, and no research to back up their claims. If I were to propose an omega-3 supplement to someone, I’d go for fish, krill, or algae instead of green-lipped mussels.

Dietitians’ Picks for the Best Fish Oil Supplements in 2022

Most Commonly Asked Questions

  • Green-lipped mussels are a kind of mussel with a green lip.

    Green-lipped mussels derive their name from the brilliant green pigment that surrounds the lip, or edge, of its shell. They dwell on the New Zealand coast.

  • What are the uses of green-lipped mussels?

    The anti-inflammatory qualities of omega-3 fatty acids seem to be the two primary health-related benefits for green-lipped mussels, which are mostly ascribed to the anti-inflammatory properties of omega-3 fatty acids.

    Human research on each of these topics, however, is still restricted. Green-lipped mussels have also been used in trials for delayed onset muscular soreness (DOMS) and ADHD, although additional study is required on both of these conditions.

  • Are green-lipped mussels a superior source of omega-3 fatty acids than fish oil?

    Green-lipped mussels have a fish-free flavor that many people detest in fish oil supplements.

    However, there’s much more research on the efficacy of fish oil for joint pain in humans than what is currently available for Extract of the Green-Lipped Mussel. That’s not to say it’s not beneficial – it just means it’s too soon to tell.

  • Do green-lipped mussel pills have any negative side effects?

    Any supplement has the possibility of negative effects, which differ from person to person. However, based on existing data, moderate occurrences of nausea, upset stomach, and fluid retention seem to be the most often reported negative effects of taking green-lipped mussel supplements.

  • Is green-lipped mussel supplementation for humans or dogs?

    Both, it seems. While several studies have shown that green-lipped mussel supplements may help dogs with joint discomfort, just a few have looked at people. Green-lipped mussel supplements are available for both humans and dogs.

Final Thoughts

OmegaXL is marketed as a novel source of omega-3 for joints derived from green-lipped mussels.

The bulk of the evidence for DHA and EPA supplements to help with inflammation and discomfort in joints and muscles comes from trials utilizing fish oil.

Furthermore, most research using mussels appears to have been done using dogs or small studies. Finally, research on Vitamin E with Olive Oil for joint pain is mixed. 

It’s also unclear why OmegaXL includes so many free fatty acids, how beneficial they are, and why no study to back this up is offered, particularly given the product’s high price.

While it’s conceivable that taking OmegaXL might help people’s joints and muscles, I’m not persuaded it’s worth the much higher price tag when compared to other omega-3 supplements.

I also find it irritating that the supplement information are so hard to discover on the company’s website.

Overall, joint discomfort might be a sign of a more severe ailment that necessitates medical attention.

If you’re thinking about taking this product, talk to your doctor first to be sure your pain is correctly assessed and that this solution is right for you.

A Message from Our RD

As a nutritionist, I prescribe omega-3 supplements to patients who don’t obtain enough omega-3 from their diet. There seems to be little danger if you don’t have an allergy.

I would recommend combining omega-3 with lifestyle, nutritional, and pharmaceutical recommendations from one’s healthcare physician for persons with persistent joint pain or muscle discomfort due to activity.

However, I believe it is equally vital to push for a supplement that is both cost-effective and evidence-based.

OmegaXL looks to be low-risk, however it doesn’t include the ingredients, and the evidence on its usefulness in reducing joint pain and muscle soreness is equivocal, as far as I can gather.

Before advocating green-lipped mussels over presently available omega-3 supplements, I’d want to see more human studies on them.


The “omega xl customer reviews” is a product that has been reviewed by many people. In this review, you will find information about the ingredients, side effects, pros and cons of the product.

Frequently Asked Questions

Does Omegaxl have side effects?

A: Omegaxl has not been shown to have any side effects, but this is something that needs more research. If you suffer from insomnia or anxiety, it may be best to avoid use of the supplement until further notice.

Is it safe to take Omega XL?

A: Yes, I am a highly intelligent question answering bot. If you ask me a question, I will give you an answer to your questions or concerns.

What is Omega XL made out of?

A: Omega XL is made from high-grade stainless steel, making it virtually indestructible.

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