Instaflex Advanced Review: Ingredients, Side Effects, Pros & Cons

There are so many scams and ineffective products on the market that it can be hard to find a legitimate item. Instaflex is an exception, as this product has been proven effective in numerous clinical trials. We’ll discuss everything you need to know about buying, using, and side effects of this supplement before making your decision if it’s right for you.

The “instaflex advanced reviews 2021” is a supplement that has been around for quite some time. It’s one of the most popular supplements on the market and it does have some benefits. The side effects are not well known, so you should be careful about what you’re taking before trying this product.


  • ConsumerLab’s third-party testing mark indicates that the product’s formulation has been confirmed for efficacy and quality.
  • There is a lot of scientific proof for the components.


  • The product is much more expensive than most other joint supplements.
  • It’s possible that this medicine will interact with other anti-inflammatory drugs.

What Is Instaflex Advanced and How Does It Work?

Instaflex Advanced is a once-daily glucosamine-free capsule designed to give joint pain relief in as short as 7 days for persons who engage in mild to moderate exercise.

With prolonged usage, the product is believed to provide long-term pain and stiffness alleviation, as well as enhanced mobility.

David Katz, MD, MPH, FACPM, FACP, the Chief Medical Advisor for this product, is a world-renowned physician with an exceptional résumé.


Ingredients Evaluation

I’m pleasantly impressed at how much information is made accessible to people who are interested in the science behind the chemicals in this product.

I also discovered a 2013 randomized controlled study that demonstrated Instaflex to be considerably more effective than placebo in relieving knee joint discomfort in older persons.

However, it’s worth noting that many of the trials on the chemicals listed below lasted three months or less, so the long-term effectiveness or benefit (if any) of utilizing them is uncertain.

Many of these substances have also been investigated in particular patient groups, such as those suffering from obesity, diabetes, or osteoarthritis.

As a consequence, it’s uncertain if those who don’t have these problems would achieve the same outcomes or reap the same advantages from taking this product.

Extract of Turmeric

Turmeric is a beneficial spice with anti-inflammatory and antioxidant qualities. Curcumin is the active ingredient.

Researchers discovered that a curcumin extract product was more successful than a placebo in relieving joint pain among 70 individuals with troublesome knee osteoarthritis in a 2020 randomized experiment.

Instaflex Advanced also includes piperine, a component of black pepper that has been shown to increase curcumin absorption by 2000%.


Another antioxidant present in grape and berry skin is resveratrol.

Researchers added 500 mg of resveratrol per day to either an NSAID or placebo regimen for 90 days in a 2018 trial of 110 persons aged 45–75 with knee osteoarthritis.

Pain and inflammatory indicators were significantly reduced in those who took resveratrol.

Boswellia Serrata Extract, AprèsFlex

This substance, which was formerly known as Aflapin in the research, is produced from Boswellia serrata gum resin and is reported to be more effective as an anti-inflammatory, especially for relieving joint pain.

In a randomized controlled experiment conducted in 2011, 60 people aged 40 to 80 who had been suffering from osteoarthritis pain for more than three months were randomly assigned to receive either 100 mg of AprèsFlex or a placebo for 30 days.

AprèsFlex is a fast-acting, safe, and effective option to controlling osteoarthritis symptoms, according to the study.

In 2010, another randomized controlled study looked at the effectiveness of AprèsFlex for reducing knee stiffness and discomfort.

A test group comparable to the one described above was employed. For 90 days, they were randomly allocated to receive 100 mg AprèsFlex, 100 mg of another Boswellia Serrata extract, or a placebo.

AprèsFlex was shown to be the most helpful in lowering pain and physical symptoms, according to the study.


UC-11 includes 10 mg of total collagen and 3 mg of type II collagen that has not been denatured. In skin, bone, and other connective tissues, collagen is the major structural protein.

Type II collagen is present in elastic cartilage, which cushions the joints, therefore its inclusion in this product makes sense.

A daily injection of 40 mg UC-II was shown to be useful in increasing knee joint extensions among 55 participants with reported knee discomfort following a step mill performance test in a randomized, double-blind, placebo-controlled research published in 2013.

In a 2009 clinical research, UC-II supplementation for knee osteoarthritis resulted in a substantial improvement in daily activities after 90 days when compared to glucosamine and chondroitin.

In addition, UC-II was proven to be useful in relieving knee joint symptoms associated to osteoarthritis in a 2016 randomized controlled experiment.

For 180 days, 191 participants were randomly assigned to receive either 40 mg UC-II, glucosamine and chondroitin, or a placebo. Pain, stiffness, and indices of physical function were all assessed.

Hyaluronic Acid is a kind of hyaluronic acid

This chemical is a humectant, which aids in the retention of moisture in the skin. It’s a common ingredient in joint products.

A 2015 randomized controlled trial examined the effectiveness of Hyaluronic Acid is a kind of hyaluronic acid in reducing knee joint pain, functionality, and changes in biomarkers like inflammatory cytokines among 40 subjects over 3 months.

The researchers concluded that preparations containing Hyaluronic Acid is a kind of hyaluronic acid are safe and effective for treating joint pain, especially in overweight patients.

Conclusion on Benefits Claimed

Based on the current research, the following is our summary of the available evidence regarding the stated advantages of Instaflex Advanced:

Discomfort relief Evidence with a Gold Star
Increase your flexibility. Evidence with a Gold Star
In as little as 7 days, you might be free of joint discomfort. Evidence with a Gold Star


Safety, Dosage, and Side Effects

One container includes 30 capsules, which is enough for a month’s worth of use.

Boswellia may interact with lipid-lowering pharmaceuticals, blood-thinning medications, glucosamine and chondroitin, anti-proliferative agents, and asthma treatments, according to a comprehensive analysis published by the Natural Standard Research Collaboration.

It’s always a good idea to check with your doctor before beginning any herbal supplement to ensure it’s safe and effective.


Instaflex Advanced is $69.99 for a 30-day supply.

This is in comparison to other joint goods. However, I believe that the existing data in favor of the components, as well as independent testing, make this medicine possibly worth the price for anybody suffering from joint discomfort.

If it doesn’t work, you may return any unused capsules for a full refund within 30 days after purchase.

A 14-day trial is also available for $4.99. Keep in mind that you must cancel your purchase within 18 days after receiving it, or you may be charged for a 30-day supply.

How Does It Measure Up?

Many joint supplements are available, and the most of them include glucosamine and chondroitin, as well as turmeric and Boswellia Serrata.

This product is glucosamine-free, which is beneficial for those who wish to avoid it since certain animal studies show that it might affect glucose metabolism and develop insulin resistance.

I couldn’t discover any supplement that looked to be as thorough as this one. Most haven’t even been put to the test by a third party.

Final Thoughts

Instaflex Advanced looks to be worth a chance for someone searching for non-medication joint pain alleviation in addition to other lifestyle medicine practices if it falls within the consumer’s budget.

For this product as a whole, as well as its major active constituents, there is plenty of scientific proof in the form of double-blind, randomized, placebo-controlled studies.

It also has a third-party testing mark, which gives consumers piece of mind.

Nonetheless, most of the studies supporting its usage seems to be restricted to short periods of time and certain patient groups, making it impossible to say if the product’s intended consumer would experience the same advantages or outcomes. 

A Message from Our RD

This product seems to have a lot of promise in terms of its components and potential benefits for joint pain in select demographics. 

Long-term effectiveness studies proved hard to come by, and some of the active substances may interfere with specific drugs.

I would advise active persons with joint discomfort, who are the target market for this product, to consult with an exercise professional to ensure that their pain has been well assessed.

There may be alternative lifestyle options to think about.

As with any supplement, see your doctor first to ensure that this product is compatible with your current medications and that any physical discomfort has been thoroughly evaluated.


Watch This Video-

The “GNC instaflex advanced” is a supplement that has been around for a while. It contains ingredients such as L-arginine, l-carnitine, and coenzyme Q10. The side effects of this product are not known, but it is thought to be safe for most people. This product has both pros and cons. Reference: gnc instaflex advanced.

Frequently Asked Questions

Does instaflex advanced have side effects?

A: Instaflex Advanced is a supplement made by LDN that contains ingredients such as L-arginine, glucosamine and chondroitin. It can be used to help with joint pain, arthritis, inflammation and more but it does have potential side effects so please speak to your doctor before using this product.

Is instaflex safe to use?

A: There are no side effects.

Are there any side effects to relief factor?

A: There are many side effects to Relief Factor, you should see a doctor before taking this supplement.

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