ProstaGenix Review: Ingredients, Side Effects, Pros and Cons

ProstaGenix is a supplement that promises to help alleviate symptoms of menopause. It contains ingredients like saw palmetto and pygeum, which are marketed as natural alternatives for the treatment of similar conditions. The product also has other benefits such as improved nail strength and hair growth. However, there are some side effects associated with this supplement (such as dry mouth) but it can be worth your while if those risks don’t bother you .

The “prostagenix bad reviews” is a supplement that claims to help you lose weight. It has been said that the product does not work and there are side effects from taking it. There are also Pros and Cons of using this product.


  • Provides a strong 90-day money-back guarantee as well as a phone number to contact.
  • Beta-sitosterol seems to have a minimal risk of adverse effects and excellent data supporting its ability to alleviate BPH symptoms.
  • A few of the substances may be useful in the treatment of prostate symptoms.


  • There is no approved third-party testing seal on the product.
  • Many of the substances have little or no human evidence to support their usage in prostate health.
  • Many alternative prostate health products are less pricey.

What Is ProstaGenix and How Does It Work?

ProstaGenix is the first and only prostate supplement with more than 1,000 mg of mixed sterols to enhance prostate health, according to the company.

It claims to be the highest-rated prostate supplement in history, with Larry King, the late spokesman, praising it.

There are various fascinating claims regarding how it might help with prostate issues ranging from urination problems to sexual function.

As a trained dietitian, I’m always wary of supplements that make large promises up front but fail to provide scientific support in the form of peer-reviewed research.

To analyze the formulation of this product, I had to do a lot of digging into the research, which I believe would be useful for customers to see right away.


Men’s Prostate Health as They Age

Prostate problems in men become more frequent as they become older. Prostate cancer is the greatest cause of mortality among males due to cancer.

Benign prostatic hyperplasia (BPH), often known as an enlarged prostate, is a common disorder that causes urinary pain, reduces urine flow, and increases the risk of urinary tract or kidney problems.

Prostate-specific antigen (PSA), a protein generated by prostate gland cells that might suggest prostate cancer or urinary problems, can be elevated by BPH.

Men who suffer from these problems understandably have a worse quality of life and are yearning for a non-invasive, more natural solution to enhance their prostate health. This is exactly what ProstaGenix aspires to do.

Ingredients Evaluation

ProstaGenix has Beta-sitosterol as its main active component, with a polyphenol blend and an 11-vitamin and mineral combination rounding out the recipe.

Most of the substances in its composition were subjected to a review of the existing prostate health research.

1,050 mg BetaRexin Proprietary Sterol Blend

The following ingredients make up this blend:

  • Beta-sitosterol
  • Campesterol
  • Stigmasterol
  • Brassicasterol

Because beta-sitosterol is the most important element in ProstaGenix, I’ll start there. Each serving of this sterol combination contains 852 mg of beta-sitosterol.

This plant-derived chemical is often used to decrease cholesterol and alleviate the symptoms of an enlarged prostate.

It reduces inflammation by limiting the amount of cholesterol that may enter the body and bind to the prostate.

Although beta-sitosterol seems to help with enlarged prostate symptoms, it does not appear to shrink prostate size.

When coupled with additional compounds, efficacy does not seem to increase.

However, a 1999 study found that it relieves urination symptoms and increases urinary flow in those with BPH, however additional research is needed.

Beta-sitosterol has also been demonstrated to be an effective therapy for BPH in earlier research.

In a 1997 trial, for example, researchers administered 177 men from 13 study locations 130 mg free beta-sitosterol daily for six months while monitoring BPH symptoms.

They discovered that beta-sitosterol outperformed placebo and concluded that it is an effective therapy for BPH.


Though the bulk of research are over 20 years old, beta-sitosterol provides strong evidence to support its effectiveness in treating BPH symptoms.

300 mg Target Polyphenol Synergistic Blend

The following ingredients make up this blend:

  • Extract of Grapeseed
  • Pomegranate Seed Extract is derived from the seeds of the pomegranate
  • Quercetin

Although their effectiveness as part of this combo is unknown, and most study has been done on animals in laboratories, these chemicals seem to have some evidence supporting their anti-prostate cancer usage.

According to certain studies, quercetin possesses anticancer properties and might be useful in prostate cancer prevention.

Antioxidants abound in pomegranate extract. It has been proven to limit the development of prostate cancer cells and cause cell death in vitro, but in a major placebo-controlled experiment, it had no meaningful impact on prostate cancer outcomes.

According to a 2009 research, grape-derived compounds have a wide range of anticancer properties, including for prostate cancer.

Furthermore, Extract of Grapeseed has been observed to have in vivo anti-cancer efficacy against certain prostate cancers using animal models.

According to the website, a 2011 survey of 35,239 males aged 50 to 76 years old was done. Using a dietary frequency questionnaire, researchers discovered that taking grapeseed supplements was linked to a 41% decreased overall risk of prostate cancer.

Nonetheless, the authors found that there is insufficient data to recommend grapeseed for cancer prevention.


Extract of Grapeseed, Pomegranate Seed Extract is derived from the seeds of the pomegranate, and Quercetin have antioxidant properties and may offer anticancer benefits, but more research on prostate cancer is needed.

400 IU Vitamin D3

The function of vitamin D in prostate health, particularly prostate cancer, is debatable, with inconsistent results.

According to a 2013 study, the influence of vitamin D on prostate volume and BPH seems encouraging, with enough vitamin D consumption perhaps helping to shrink enlarged prostates, although further research is required.

A research on mice discovered that mice that were lacking in vitamin D had increased prostate cancer development in their bones, indicating that receiving enough of this mineral is critical for prostate health.

High-dose vitamin D pills, on the other hand, do not seem to be useful for men with prostate cancer, according to a 2019 meta-analysis.

While there was no link between blood vitamin D levels and prostate cancer in a 2020 research, men with prostate cancer who are also vitamin D deficient may have a greater mortality risk.

Vitamin D insufficiency has been linked to an increased risk of a variety of other health problems, including weakened immunity and bone fractures, which become more common as people become older.

While the evidence on prostate health is mixed, ensuring that your blood vitamin D levels are within the normal range is a recommended preventative health practice.

ProstaGenix provides 400 IU of vitamin D3 every day, which is equivalent to 100% of the RDA for this age group.

This quantity is more of a preventative or maintenance dosage than a high-dose, which, according to the aforementioned studies, may cause hazards.


Suggesting men with prostate health difficulties, high-dose vitamin D isn’t suggested, and the evidence for a link between vitamin D and prostate health is inconsistent.

However, avoiding vitamin D insufficiency is a good idea, particularly for this age range, and the quantity in ProstaGenix reaches 100 percent of the RDA without going over.

150 mcg iodine

There wasn’t much study on the link between iodine and prostate health that I could uncover.

However, the authors of a 2007 study suggested that additional research into how thyroid dysfunction may raise the risk of prostate cancer should be conducted.

They also said that the significance of iodine is yet unknown.

Furthermore, although iodine supplementation has been shown to have antitumor benefits in numerous forms of cancer, a 2013 animal research found that it had no impact on preventing prostate cancer growth in mice.

ProstaGenix contains 150 mcg of iodine, which is 100 percent of the RDA for this age group.


Although there is no direct relationship between iodine and prostate health, enough iodine intake is necessary for overall health, and this supplement delivers 100% of the RDA.

15 mg zinc

Zinc is a micronutrient that has been linked to healthy immunological function.

The human prostate has a high quantity of zinc, yet evidence on the relationship between zinc and prostate cancer is conflicting.

Chronic zinc excess has been linked to the development of prostate cancer, according to a 2003 research.

Zinc transporters, on the other hand, may have a role in prostate tumor suppression, according to new study.

Furthermore, although epidemiological studies have shown conflicting findings, there is evidence that zinc may have a preventive effect in prostate cancer, according to a 2009 study.

In a 2011 research, the authors discovered that normal zinc status was lowered by 83 percent in men with prostate cancer and by 61 percent in individuals with BPH, suggesting that zinc status and prostate health are linked.

Zinc deficiency is linked to an increased risk of various prostate health disorders in males over 50, including BPH and prostate cancer, according to a more recent 2020 research.

ProstaGenix contains 15 mg of zinc, which is 100 percent of the RDA.


Zinc deficiency has been linked to an increased risk of prostate problems in males over the age of 50, according to study. ProstaGenix meets 100 percent of daily zinc requirements.

70 mcg selenium

In a 2019 clinical experiment, 481 males were given 200 mcg of selenium per day for six months and their PSA and selenium levels were assessed before and after supplementation.

Selenium alterations were shown to be highly reliant on baseline selenium levels, and selenium supplementation had no effect on PSA levels, according to the scientists.

However, among younger, never-smokers who ingested more than the RDI for zinc but less than the RDI for vitamin B12, there was an inverse relationship between PSA and selenium changes.

According to other studies, even little selenium deficiency might raise the risk of prostate cancer.

According to a 2011 Cochrane analysis, males who consumed the most selenium had a 22 percent reduced risk of prostate cancer than those who consumed the least.

In addition, a meta-analysis from 2003 that included 20 epidemiologic studies indicated a possible negative association between selenium levels and prostate cancer risk.

When it comes to selenium, remember that more isn’t necessarily better. Toxic effects might occur if you consume too much selenium.

The good news is that ProstaGenix meets the RDA for selenium without going overboard, but users should avoid using selenium-containing products like a multivitamin.


It seems that getting enough selenium is critical for men’s prostate health, but it’s a tricky balance. The RDA for selenium is met with this supplement.

Additional Ingredients

  • 2 mg copper
  • 2 mg manganese
  • 120 micrograms of chromium
  • 70 mcg molybdenum

While these trace minerals are included in the ProstaGenix recipe, there is little evidence on their direct relationship to prostate health.

Manganese supplementation has been shown to reduce the viability of prostate cancer cells in certain studies, whereas chromium (VI) has been shown to increase prostate tumor growth in others.

Copper levels in the blood have been discovered to be higher in prostate cancer patients.

For these four trace elements, ProstaGenix delivers 100% of the RDA.


I couldn’t uncover any evidence of a link between these four nutrients and prostate health, but ProstaGenix delivers the RDA for them in the same way that a multivitamin does.

Conclusion on Benefits Claimed

Based on the existing studies, we’ve compiled a summary of the available evidence regarding ProstaGenix’s stated benefits:

Reduces urination at night Evidence of Moderate Strength
Reduces the sense of urgency Evidence of Moderate Strength
Improves the emptying of the bladder Evidence of Moderate Strength

Although there is evidence that beta-sitosterol, in particular, may benefit men with BPH symptoms, much of the study is outdated.

The Additional Ingredients in ProstaGenix offer mixed evidence and are largely based on animal studies.

Overall, there is Evidence of Moderate Strength that the product may help reduce nighttime urination and urgency and help improve bladder emptying.


Safety, Dosage, and Side Effects

ProstaGenix is taken three times a day as a single capsule. They may be taken at any time of day, on an empty or full stomach, according to the instructions.

Each container includes 90 capsules, which is enough for a month’s supply.

According to the company, most men get results during the first 10 days of usage, and after 3–4 weeks of regular dosage, they see results more consistently.

Each ProstaGenix dosage also includes 852 mg of beta-sitosterol, according to the manufacturer.

While no standardized dose seems to exist, randomized controlled studies on BPH between 1966 and 1998 employed beta-sitosterol doses of 60 to 195 mg/day with moderate efficacy for urinary symptoms, according to an earlier Cochrane review.

It’s unknown why ProstaGenix employs such a large proportion.

The only thing I could find out about taking greater dosages of beta-sitosterol (1200–1800 mg per day) is that it may help decrease LDL “bad” cholesterol, which might be a plus for this demographic.

Men with sitosterolemia, a rare genetic illness in which the body stores too much beta-sitosterol and associated lipids, should avoid using beta-sitosterol products like this.

According to my research, beta-sitosterol has a minimal chance of adverse effects, however it may cause moderate digestive troubles in some individuals and can sometimes cause erectile dysfunction.

These tend to be among the most often reported negative effects of comparable prostate health nutraceuticals, which may be beneficial for customers seeking them, given that medical therapy for BPH is not without danger.

In a case report published in 2020, a 57-year-old man with a history of BPH said that his usage of beta-sitosterol caused pancreatitis, which necessitated hospitalization.

When he stopped taking the product, his symptoms went away.

While he only took it for two days, there’s no indication of how much he took, and it’s crucial to remember that this is just one person’s experience.

Regardless, this emphasizes the necessity of just taking supplements as advised and selecting supplements with proven safety and effectiveness.

BPH symptoms may be caused by a variety of factors, some of which are potentially dangerous. Before using a supplement for prostate health, talk to your doctor, particularly if you have urinary symptoms.

Furthermore, despite the fact that the product claims to have been evaluated for quality and purity by a third-party laboratory, ProstaGenix lacks an official third-party testing mark, which would provide greater confidence to the product.

The front of the bottle says “Verified Nutrition Laboratory Tested,” yet there are no significant independent testing bodies listed.

ProstaGenix boasts that it was named the best prostate supplement by the National Health Federation in 2017.

While the website claims that the NHF is “the world’s oldest non-profit health organization,” it fails to mention that the NHF is a lobbying organization that promotes dietary supplements and alternative medicine while opposing evidence-based public health initiatives such as childhood vaccinations and fluoridated water.

Professional groups such as the American Cancer Society are hostile to NHF-promoted items.

ProstaGenix does, however, have an award from the respected independent testing firm for winning a prostate testing competition, which examined label claims to determine whether they matched the ingredients in the bottle.

In addition to receiving a good rating, the product was deemed to be the greatest value for beta-sitosterol among the products tested.

Finally, I would encourage ProstaGenix customers to be mindful of any additional supplementary sources of the micronutrients contained in this product, since it already includes 100% of the RDA for several vitamins and minerals.

Taking extra sources of certain nutrients may lead to overconsumption, which can be troublesome when supplements are used.

Where to Buy and How Much

ProstaGenix is available for purchase on the company’s website as:

  • $49.95 for one bottle
  • $99.95 for a three-pack
  • $149.95 for a 5-pack

If you’re not happy with your purchase, the firm provides a 90-day money-back guarantee, excluding shipping and handling taxes.

ProstaGenix may also be found by doing a fast search on Amazon, where the price fluctuates.

How does ProstaGenix stack up against the competition?

Beta-sitosterol is seen in many prostate health products, which makes sense since it seems to have the greatest proof.

ProstaGenix looks to contain more ingredients and costs more than competing brands.

ProstaGenix claims that saw palmetto and lycopene are “worthless gimmicks” in many other prostate products.

I’m not sure whether this is correct, but it seems that there isn’t enough evidence for saw palmetto or lycopene to be effective in treating BPH urinary symptoms on its own.

More study on lycopene is required, according to studies, since there isn’t enough proof to reject its potential in this field.

Even huge dosages of saw palmetto had no impact on urine flow or prostate enlargement, according to a 2012 Cochrane analysis. Other research on these two chemicals in combination, however, has shown some promise.

For example, a 2018 clinical research of 400 men revealed that a combination of saw palmetto, selenium, and lycopene was just as effective in treating lower urinary tract symptoms as the regularly recommended BPH medicine tadalafil.

In a 2014 trial, a combination of saw palmetto, lycopene, and selenium with tamsulosin was shown to be more effective than individual therapy in increasing BPH urine flow rate.

Still, beta-sitosterol is the component with the greatest research behind it for prostate health, and ProstaGenix has more per dose than other prostate supplements.

Most other choices have 400–800 mg of beta-sitosterol per serving, however ProstaGenix has 852 mg of beta-sitosterol each serving, along with additional sterols.


Overall, ProstaGenix has several elements that may assist prostate health, with a strong amount of beta-sitosterol emphasized for helping to alleviate BPH symptoms.

ProstaGenix may be worth the money for certain guys, and it seems to have a lower risk of negative effects than other prostate supplements for most healthy individuals.

Related: 2022’s Best Prostate Health Supplements

Final Thoughts

ProstaGenix is promoted as the most scientifically validated prostate health product available.

Although most of the studies are old, there is human evidence for utilizing beta-sitosterol to improve symptoms of common prostate complaints in men with BPH.

The majority of evidence behind the Additional Ingredients in the formulation is mixed and heavily based on animal research.

It’s likely that ProstaGenix might aid in the treatment of BPH symptoms. It also looks to be low-risk in terms of side effects, as long as users are aware of any other supplements they’re taking that include the vitamins and minerals in this formulation in order to prevent toxicity or negative interactions.

As a result, ProstaGenix may be worth a try.

Before purchasing this product, men with prostate issues should see their doctor for a proper diagnosis and treatment suggestions.

Our Dietitian’s Remarks

This supplement, like many others, appeals to men looking for a different way to manage BPH-related urine symptoms while also boosting overall prostate health.

While it seems that the greatest danger of taking this product is that it does not work and produces minor digestive side effects, I would first look at your general food habits.

According to research on BPH and nutrition, lifestyle changes such as limiting alcohol and dairy intake and increasing polyunsaturated fats and vegetables are more effective than supplements in improving lower urinary symptoms.

A healthy whole foods-based diet is more likely to improve other parts of life and BPH symptoms, which is always a good investment and, in my view, should be emphasized first.

Before self-diagnosing or medicating with this product, as with all nutraceuticals, check with your doctor to confirm it’s suitable and that any symptoms have been appropriately examined.


ProstaGenix is a supplement that has been on the market for a while. It claims to help people with prostatitis and prostate cancer. The product also offers other benefits such as increased testosterone levels, increased libido, and more. Reference: prostagenix benefits.

Frequently Asked Questions

Is it safe to take ProstaGenix?

A: ProstaGenix is safe to take and has no known side effects.

Can ProstaGenix cause cancer?

A: ProstaGenix is a supplement that helps testosterone levels in men. Its not been found to cause cancer, but it has been linked with heart problems and other side effects if taken without the advice of your doctor

What are the side effects of prostate supplements?

A: The side effects of prostate supplements can vary depending on the person, so they are pretty hard to generalize. However, in most cases it is known that men who have had their prostates removed may experience a decrease in seminal fluid secretion and/or ejaculation volume due to decreased levels of testosterone. Additionally, some patients might continue producing urine even after urination has ceased while others might be unable to do so at all leading them into complete urinary incontinence.

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