Nucific BIO

Nucific’s BIO is one of the best-selling whey protein supplements on, and it has been in circulation for about a decade. This product contains a blend of proteins that includes pea, quinoa seed, brown rice flour, and gum arabic extracts.

Nucific BIO is a supplement that claims to help you get rid of unwanted weight and improve your overall health. The product has been rated 4 out of 5 stars on Amazon. Read more in detail here: nucific bio x4 amazon reviews.


  • Some substances have been shown to work.
  • Gut health may be aided.
  • Allergen-free, gluten-free, and lactose-free
  • Money-back guarantee for 90 days

  • There is a scarcity of compelling data on the advantages of weight reduction.
  • For a 30-day supply, it’s rather pricey.
  • Most individuals do not need digestive enzymes.

What Is Nucific BIO-X4 and How Does It Work?

BIO-X4 by Nucific is a nutritional supplement that promotes healthy digestion and metabolism.

This product promises to provide a potent 4-way defense plan against a voracious appetite, food cravings, indigestion, and a sluggish metabolism.

Nucific was founded by Dr. Amy Lee, an internal medicine specialist who specializes in obesity care.

The company’s stated purpose is to provide cutting-edge, science-backed goods that enable your body to function as it was intended.

BIO-X4 is a weight-loss supplement that includes probiotics, digestive enzymes, and other substances, according to the maker.

BIO-four X4’s main health claims are as follows:

  • It takes care of “junk” cravings.
  • It encourages weight loss.
  • It promotes easier digestion.
  • It increases metabolism.

Special Promotion


BIO-X4 is available for purchase.

Discounts of up to 40% are available.

Shipping is completely free.

Money-back guarantee for 90 days

Ingredients Evaluation

BIO-X4 is made up of the constituent blends listed below, which are meant to generate the desired results. The following component quantities are for one capsule alone.

Take at least one capsule with each meal and up to six capsules per day, according to the manufacturer’s instructions.

Multiple substances are used in the Probiotic and Digestive Enzyme mixes. As a result, the individual dosages of the ingredients in these two mixes remain unknown.

4 Billion CFUs Probiotic Blend

Blend of Lactobacillus and Blend of Bifidobacterium are the two bacterial mixtures that make up the Probiotic Blend.

Blend of Lactobacillus

Lactobacillus is a kind of good bacteria that helps with digestion and general health.

The Blend of Lactobacillus contains three specific strains: L. acidophilus, L. rhamnosus, and L. plantarum.

Lactobacillus strains are one of the most extensively researched probiotics.

Lactobacillus bacteria are found in little amounts in our bodies. However, if there are more harmful bacteria strains than beneficial bacteria strains, our health may be harmed.

Certain Lactobacillus strains have been shown in several trials to aid in the management of digestive disorders.

A 2018 scientific review on L. rhamnosus, for example, found that it relieved digestive problems including constipation and diarrhea.

In addition, according to a study published in 2020, L. acidophilus may be useful in the treatment of acute and chronic diarrhea, as well as antibiotic-associated diarrhea.

A 2019 animal research showed promise for L. plantarum’s capacity to promote a healthy digestive tract and microbiota. However, findings from a mouse research may not be replicated in people.


The Lactobacillus strains included in this product have been linked to improved gut health, especially in cases of antibiotic-associated diarrhea.

Other product claims, such as controlling “junk” appetites and causing weight reduction, have less evidence.

Blend of Bifidobacterium

One of the most common bacteria strains found in the gastrointestinal system is Bifidobacterium.

Bifidobacterium lactis and Bifidobacterium animalis are two strains found in BIO-X4.

In a short research published in 2010, B. lactis was reported to decrease gastrointestinal symptoms like constipation.

Another analysis published in 2014 indicated that B. animalis had a preventive effect against diarrhea, particularly antibiotic-associated diarrhea.


Some study on the Bifidobacterium strains in BIO-X4 has been encouraging, but the appropriate CFU number to generate these benefits is unknown.

Furthermore, some of these studies suggest a link between this strain and digestive issues rather than a clear cause-and-effect relationship from supplementing with this probiotic.

43 mg Digestive Enzyme Blend

Amylase, lipase, and bromelain are the three digestive enzymes included in this combination.

Amylase breaks down carbohydrates, whereas lipase breaks down fat.

Amylase and lipase are enzymes present in bananas, papayas, mangoes, and avocados, among other foods.

While both enzymes are required, unless you have a shortage, there is likely no need to take them as supplements.

Bromelain is a protein-digesting enzyme that has been examined for a variety of health advantages, including respiratory disorders and diarrhea. Pineapples contain bromelain.

Bromelain has the ability to prevent diarrhea in animals caused by infections like E. coli, according to a 2012 scientific review.

Human studies on bromelain’s effect in aiding digestion in the absence of illness are, however, limited.


It’s uncertain whether ingesting this combination can help you unless you have a documented digestive enzyme deficit.

100 mg Weight Management Blend

Green tea extract (GTE) is the key element in the weight control mix. The extract includes 50% EGCG, a plant chemical found in green tea leaves that is considered to be responsible for many of the tea’s well-publicized health benefits.

EGCG has been shown to increase metabolism and burn fat. However, there is a mixed bag of evidence in this area.

While some studies have shown EGCG to boost fat metabolism, others have not, according to a 2013 review.

Positive findings were observed in several of the trials analyzed addressing its fat-burning capacity in individuals ingesting at least 270 mg of EGCG per day.

If you take three Nucific BIO-X4 capsules per day at a dosage of 50 mg EGCG each capsule, you’ll get 150 mg EGCG per day.

According to the manufacturer, you may take up to 6 capsules per day for a total of 300 mg EGCG to optimize the fat-burning capabilities of this product.


Several studies have shown that green tea extract and its primary ingredient, EGCG, may help people lose weight. However, most research to far have been modest in scope, and larger studies would be beneficial in determining the advantages for the general public.

166 mg Craving Control Blend

Slimaluma is a “craving control” compound found in BIO-X4.

Caralluma fimbriata, abbreviated as CFE, is the scientific name for the component. It’s made from a cactus that’s native to India. This extract may decrease hunger, according to certain ideas.

CFE was the subject of a 2015 randomized research that found no advantage in taking it, despite the fact that it was well tolerated.

A more recent randomized controlled experiment from 2021 shown a stronger impact.

The CFE group consumed roughly 245 less calories per day on average during the course of the four-month research. They also shed more weight and saw their waist circumference shrink.

While these findings seem more promising, the CFE group only dropped approximately an inch off their waistlines and shed less than a pound on average. This isn’t a really significant weight loss in four months.

The optimal dosage of CFE for achieving benefits is currently being researched.


Caralluma fimbriata is a plant extract that has been shown to help with weight reduction and appetite suppression. It has some promise for utilization, but the research so far hasn’t been persuasive enough to establish that it has a major effect on weight.

Conclusion on Benefits Claimed

Based on the existing studies, we’ve compiled a summary of the available evidence regarding Nucific BIO-stated X4’s benefits:

Controls “junk” food urges Evidence of Moderate Strength
Weight loss is encouraged. Evidence of Moderate Strength
Aids in the digestive process. Evidence of Moderate Strength
Increases metabolism Evidence of Moderate Strength

Some of the claims stated for this medication, such as its ability to reduce weight, decrease hunger, and alleviate digestive symptoms and diarrhea in the event of an infection, are backed up by study.

However, bigger trials on green tea extract and CFE are required to see how effective they are in helping people lose weight.

It’s unclear how much of a benefit these probiotics will have for someone who has dyspepsia that isn’t caused by an illness.

Safety and Side Effects

One capsule of BIO-X4 should be taken with each meal, according to the directions. You may take up to two capsules every meal, but no more than six capsules per day.

There are a few possible negative effects to be aware of while using this supplement.

BIO-X4 is made up of probiotics, which are usually considered to be harmless.

However, a 2019 review of data found that probiotics might cause adverse effects such gas, bloating, and diarrhea, particularly when taken for the first time.

In addition, persons who are immunocompromised may be at a greater risk of infection or sepsis while taking probiotics, according to this study.

Probiotic side effects vary depending on the probiotic strain and the health of the person. As a result, many criteria must be considered when assessing if it is safe to take.

Green tea extract (EGCG) is also included in this supplement. There have been a few cases of liver impairment reported after taking 800 mg or more of EGCG per day.

While this is alarming, the EGCG dosage in Nucific BIO-X4 is far lower.

Furthermore, according to a 2018 systematic review, up to 338 mg of EGCG in capsule form is regarded safe with low adverse effects.

Based on the quantity of EGCG in one BIO-X4 capsule, the maximum amount of EGCG you would consume each day from 6 capsules would be 300 mg.

Before beginning on this or any other supplement, always check with your doctor.

Where to Buy and How Much

The best location to get BIO-X4 is through Nucific’s official website. The cost of a 30-day supply is $99.00.

When compared to other weight reduction probiotic pills, which normally cost $20–$40 for a 30-day supply, this seems to be a little pricey.

If you purchase in bulk for a 3-bottle or 6-bottle supply that lasts 3–6 months, you’ll save money.

If you are not happy with your results after 90 days, Nucific will refund your money in full.

Despite the fact that it is cheaper on Amazon, it seems to be offered by third parties. As a result, there’s no way of knowing whether what’s on the label is what’s within the bottle.

Special Promotion


BIO-X4 is available for purchase.

Discounts of up to 40% are available.

Shipping is completely free.

Money-back guarantee for 90 days

How BIO-X4 Measures Up to the Competition

There are a few products on the market that make similar claims about digestive health and weight loss as Nucific’s BIO-X4, but few have the same mix of ingredients to achieve the same results.

New Chapter Weight Management Probiotics & Prebiotics and Hum Nutrition’s Skinny Bird are the two most comparable products in terms of health claims and ingredients.

New Chapter’s supplement also includes a blend of digestive and weight-loss substances.

It just has the bacterial strain B. animalis in it, but it’s more potent. BIO-X4, on the other hand, has a number of strains that may operate better together.

Inulin, a prebiotic included in New Chapter, may aid in the absorption of the probiotics present.

Green coffee bean extract is also included in New Chapter. This is not the same as the green tea extract in BIO-X4, although it makes comparable weight-loss promises and has similar effectiveness.

Skinny Bird by Hum Nutrition does not include probiotics, but it does contain Caralluma fimbriata (CFE) and green tea extract (GTE) for weight control, similar to BIO-X4.

The quantity of CFE in the sample is double that of BIO-X4, but the GTE dosage is lower.

Skinny Bird also includes a supplement called 5-HTP, which has been shown in certain trials to improve satiety and lower BMI.

Hum Nutrition is a supplement firm that makes more individualized supplement recommendations using quizzes.

Hum Nutrition has qualified dietitians on staff that can answer your questions and lead you to the correct supplement for your requirements.

Hum is also more open about releasing pertinent research findings on their website, which helps to strengthen their reputation.

Hum is the cheapest option at $40 per month, New Chapter’s mix is $52.63 per month, and BIO-X4 is the most costly option at $99.00 per month.

Out of all three, I would choose Hum’s Skinny Bird if you are just searching for a weight reduction supplement.

You may take a single probiotic supplement or eat fermented foods like yogurt and kefir if you need extra digestive help.

Dietitians’ Picks for the Best Probiotics in 2022

Final Thoughts

Nucific’s BIO-X4 is widely regarded as safe, with few negative effects, based on existing data. Larger research on its constituents, on the other hand, are required to demonstrate its efficacy.

It’s conceivable that some of the chemicals in BIO-X4 may cause you to lose a little amount of weight.

Although, based on the research thus far, it is unlikely to be considerably different from anything you could perform on your own.

If you’re suffering from an illness or antibiotic-related diarrhea, the probiotics in this product may be able to assist.

If you’re considering taking this or any other new supplement, talk to your doctor first to balance the benefits and drawbacks.

A Message from Our RD

According to the producers, people who live a healthy lifestyle get the most advantages from BIO-X4. As a certified dietician, I can confirm to the truth of this statement.

In my work with clients, I’ve seen time and time again that no one meal or supplement can provide substantial benefits on its own.

Instead, improving digestion and maintaining a healthy weight requires a mix of a balanced diet, frequent exercise, stress reduction, and sleep quality.

If you have indigestion or are attempting to lose weight, I recommend obtaining your probiotics through fermented foods such as yogurt, kimchi, or kombucha instead of beginning with a supplement.

These items are readily accessible in most supermarkets and may simply be included into your regular routine.

I would also recommend a diet high in prebiotic fibers, which may assist to promote the development of good bacteria while also keeping you full, allowing you to maintain a healthy weight.

Prebiotics may be found in a wide range of foods, including fruits and vegetables.

The most efficient way to achieve excellent digestion and a healthy weight is to follow these food suggestions and exercise regularly.

Nucific BIO is a supplement that is meant to improve your health. It contains ingredients like Vitamin C, Zinc, and Selenium. It also has the bio x4 nucific name because it contains 4 different types of amino acids.

Frequently Asked Questions

Is Nucific bio X4 safe to take?

A: Yes, we can confidently answer that Nucific bio X4 is safe to take.

What are the side effects of biox4?

A: Biox4 – or Bio-energy, is a type of supplement that claims to increase energy levels and improve performance. It typically contains caffeine, vitamin B3 (Niacin), Vitamin C, L-Carnitine and antioxidants like resveratrol.

Does Bio X4 make you gain weight?

A: Bio X4 is a testosterone boosting supplement that increases lean muscle mass and red blood cell production. Its not uncommon for athletes to take supplements like this, but its important to note that these are often used as performance enhancers rather than weight gainers.

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