CSUPERB Trends

I had to do it.  I used Google Trends to check out CSUPERB.

Here is the result:

Google Trends search on "CSUPERB" (12-3-2014).

Google Trends search on “CSUPERB” (12-3-2014).

Why that periodicity in searches for CSUPERB?  Well – if you dial in – the peaks are in the November-December-January timeframe. Yep.  It’s symposium season.*

The team here is fielding dozens of phone calls and emails daily and the annual CSU biotechnology symposium website is getting hundreds of hits. Symposium registration closes this evening at 5pm.  It’s also time to remember to use the #CSUPERB hashtag! Tomorrow we’ll still be nailing down the details, recruiting mentors and putting final touches on workshop designs before we all meet up in Santa Clara January 8th. Hope to see you there!


 

*Symposium season overlaps most years with rainy season in San Diego, where the CSUPERB program office is located. We are happy to report rain these last two days as well!

    Thankful for True Partnerships

    Yesterday we sent out award letters to the new 2015 Howell-CSUPERB Research Scholars, along with our annual program report to the Doris A. Howell Foundation for Women’s Health Research board.

    Howell Research Scholars are undergraduates who work alongside faculty researchers in biotechnology labs across the CSU.  For this program, the research projects proposed are relevant to women’s health.  The Howell Foundation defines women’s health quite broadly. As a result Howell projects range from basic research on the effects of ethanol on neurological development in fruit flies to clinical work to explore the links between sexually transmitted infections, sexual behavior and health outcomes in a campus setting.

    The impact of this program is best communicated by the Scholars themselves (see page 2 of the report, linked here).  As part of their final reports, we ask Scholars to self-report on their gains as a result of the research experience (click on the image below to get the larger, visible version!).  We use David Lopatto’s SURE format (mostly) to

    Students rank their learning gains as a result of undergraduate experience using a range from "very small gain" (=1) to "very large gain" (=5).  The 2014 Howell Scholars class reported average gains in the "large gain" to "very large gain" range!

    Students rank their learning gains as a result of undergraduate experience using a range from “very small gain” (=1) to “very large gain” (=5). The 2014 Howell Scholars class reported average gains in the “large gain” to “very large gain” range. Interesting, the lowest self-reported gains this year related to science writing skills.

    investigate learning gains as a result of the undergraduate research experience.  Even though most of the 2014 class of Howell Scholars had worked previously in a research laboratory, all of them reported large or very large overall benefits from the Howell-sponsored experience.

    Most scholars work on their funded projects part-time during the spring term, then immerse themselves in the project over the summer. This kind of opportunity – to take a deep dive into a single research project – remains open to only a minority of undergraduate CSU STEM students.  In answer CSU faculty and administrators continue their work to develop new external partnerships, internship programs, and project-based learning in courses throughout the undergraduate curriculum.

    Many of the Howell Scholars mentioned the importance of their faculty mentor. We know the immersive, working partnership and team-building between student, peer and faculty researchers offers a context in which students see themselves as scientists (often for the first time).  The teamwork and camaraderie students experience in working laboratories helps students persist even in the face of technical set-backs (and long experiments!).

    “…there was a week in mid July; my experiment was behind schedule, and I need to report my data to my PI the next week. I therefore decided to work full time over the weekend. I told my fellow students that they didn’t have to go. However, all of them, all 3, decided that they’ll come in anyway, to help me get my work done. It was that moment that I realized how good of a team I had with me.” – Phuc Nguyen (CSU Long Beach, 2014 Howell Scholar)

    True partnerships – shared goals, camaraderie, teamwork – are special things.  Our thirteen-year-long partnership with the Doris A. Howell Foundation is something we are thankful for here at CSUPERB.  Together we’ve been a good team!  The Howell donors remained committed to undergraduate researchers during the Great Recession; not all organizations were so steady in their giving during those years.  Likewise, CSUPERB was fortunate to maintain our budget for this program even in the face of deep cuts in state support for the CSU.

    Both CSUPERB and the Howell Foundation have a long-view (influenced by the remarkable Dr. Howell) on educating physicians, clinicians and researchers. We know the effect of two terms spent in a research group plays out over decades and careers. We look forward to hearing from our Howell Scholar alums in February; every three years we reach out to them to find out where they are.  They often write heartfelt notes; they are still exceedingly thankful for the opportunities the Howell Foundation, its board and its donors made possible.

      Waltzing Through Customer Discovery

      I’m not sure I’ve met a braver, entrepreneurial student researcher than Manmeet Singh. Ms. Singh is in the fourth year of her studies at CSU Sacramento.  She’s majoring in biology with an emphasis in Cell and Molecular Biology; she’s minoring in Chemistry and Dance.  She’s also serving as a member of the CSU I-Corps teaching team for our current student teams challenge.

      Manmeet was on the team that won the 2014 CSUPERB Idea-to-Product (I2P) Challenge last year (the precursor to the CSU I-Corps program).  But she didn’t stop there; she agreed to be the Entrepreneurial Lead (EL) on a CSU Sacramento NSF I-Corps™ Team proposal, led by Dr. Warren Smith (PI).  John Chapman (President of Stem Cell Partners, LLC), rounded off the three-person team as industry mentor (IM).  The proposal was successful and the team travelled to University of Michigan’s I-Corps™ Node this summer as part of NSF’s “national” Teams program.  They ended up winning kudos from the University of Michigan teaching team for the learning they did this summer.

      Manmeet Singh (with award in hand), John Chapman and Warren Smith receive an award "to the team that best embodied the spirit of I-Corps" from the University of Michigan I-Corps Node Teaching Team (Summer 2014)

      Manmeet Singh (with award in hand), John Chapman and Warren Smith receive an award “to the team that best embodied the spirit of I-Corps” from the University of Michigan I-Corps Node Teaching Team (Summer 2014)

      Last Friday we held the last webinar for the current group of CSU I-Corps student teams. Manmeet told her story and gave the student teams advice for “getting out of the building” and learning about product-market fit.

      Last week CSUPERB put out the call for faculty-led CSU I-Corps teams, configured just like the “national” I-Corps Teams Program (PI + EL + IM).  The NSF hopes that successful CSU I-Corps teams will go on and apply for national I-Corps Team grants, as well as SBIR/STTR, VentureWell or Lemelson-MIT prizes.

      I’m getting lots of emails and calls from interested and curious faculty members asking how this program works.  I figured the best way to answer many of their questions would be to interview Dr. Smith and Ms. Singh here as guest bloggers! I interviewed them separately, so you’ll get their different perspectives on the experience.*  Every time they refer to I2P (the program we ran 2012-2014), think of CSU I-Corps (the program going forward!).  I’ll turn it over to them to give you a candid look at I-Corps™!


      How did you meet your team members?

      Warren Smith (WDS): ” In 2010, I was Co-Principal Investigator for Sacramento State with UC Davis and Fisk University on an NSF Partnerships for Innovation (PFI) grant. That grant offered a one-week intensive Entrepreneurship Academy put on by the UC Davis Center for Entrepreneurship. John Chapman and I met as participants in that Academy. We arranged for John to be appointed as Adjunct Professor at Sac State, and John began working with teams of Sac State engineering and biological sciences students on regenerative medicine projects. Biological Sciences undergraduate student Manmeet Singh began working on these projects with John. In 2013, I got to know Manmeet when she was a member of a Sac State CSUPERB I2P team. John and I mentored her team, and that team won first place at the 2014 I2P competition in Santa Clara. That team’s product was a regenerative medicine device that was related to the product that we chose for the NSF I-Corps Teams grant.”

      Why did you want to join up and go after the NSF I-Corps Team grant?

      Manmeet Singh (MS): “Dr. Smith came to our lab and was talking about the NSF I-Corps Teams Program and said that this would be a great opportunity to connect the biology department with the engineering department…Dr. Chapman looked at me for a while and thought the Autologous Thrombin Device (ATD) would be a great project to submit and he gave me the opportunity to take the lead on the project because I know all the transformations that the device has gone through…”

      WDS: “In February 2014, NSF informed me that I was eligible to be Principal Investigator on an I-Corps Teams grant because of my previous involvement in NSF grants.** (After serving as Co-PI on an NSF PFI grant, I served as subaward Project Director on an NSF Accelerating Innovation Research (AIR) grant and am now serving as subaward Project Director on an NSF PFI:AIR grant.) From the grant description, I saw that John Chapman was a great fit to the Mentor position. He suggested Manmeet Singh as the Entrepreneurial Lead. John and I saw that the grant was a great opportunity for a student as capable as Manmeet. John saw the value of customer discovery. I wanted to learn more about what it takes to move a biomedical product to market.”

      Can you describe your current (post-U. Michigan) product concept and its value proposition?

      WDS:  “The product, the Autologous Thrombin Device, provides thrombin on demand from a patient’s own blood rapidly and at low cost to promote tissue healing. The autologous thrombin is safer than currently-used bovine thrombin.”

      MS: “It is a much safer alternative to bovine thrombin, which is derived from cow’s blood, decreasing immunological risks and foreign body reactions.”

      How did your product concept change from what it was before I2P? From what it was before you went through the U. Michigan program?

      MS: “Before the I2P competition we had the idea and a rough draft of what the product would look like but it was still going through a ton of troubleshooting experiments…The device itself along with the ratios of the fluids that we used to produce thrombin continuously changed until 8 months before we learned about the NSF I-Corps Teams Program. Our product concept and everything still remains the same as it was before the U. Michigan program but there are definitely some great things we learned through our customer interviews…”

      How did your business model canvas change from what it was before I2P? From what it was before you went through the U. Michigan program?

      MS: “During the I2P, we had a vision of our product being perfect and everyone would love it. We never really thought about or knew how many other steps are required in order to make a product idea into a reality. Before the U. Michigan Program, we had just learned about a business model canvas and we simply filled in what we knew even though we really felt like we had no idea what we were doing. However, looking back at all the business canvases…day 1 to the final presentations, it definitely showed that we had come a long way… [We now understand better] all the barriers and obstacles that one must go through simply to learn about the pains and needs of your customer segments. It was a great learning experience for sure.”

      WDS: “Before the 2013 I2P competition and the U. Michigan program, we depended on the literature and the FDA’s black-box warning label on bovine thrombin to conclude that the Autologous Thrombin Device, producing safer thrombin, would be of sufficiently widespread, recognized value to justify the formation of a manufacturing company. After the customer discovery process of the U. Michigan program, we learned that a smaller market valued autologous over bovine thrombin, so that a licensing model was more appropriate.”

      Was there an advantage of going through I2P (CSU I-Corps) before applying/attending the national I-Corps program at U. Michigan?

      MS: “For me, there was definitely a great advantage! I2P [gave me the] confidence to talk in front of a 200+ crowd. We were required to answer questions for 5-10 minutes after our presentation and the questions could have been about anything regarding our project. At least for the I2P competition you are aware that you will be asked questions at the end of the presentation; however, the National I-Corps Teams Program was an entirely different ball game! I was not only the youngest in the cohort but also the very first presenter at our first day in Michigan, and the judges were having a great time throwing rapid fireball questions at me, which they actually admitted to! Had I not had the experience of being asked questions that I was unprepared for, I probably would not have been able to survive on that stage. As soon as I started speak, two of the instructors from the teaching team shouted loudly ,”WHY?! SO WHAT?!! WHO CARES?!?!” That really frightened me because it was totally unexpected. I may not have answered all the questions appropriately but I made sure that I at least answered all of them to the best of my abilities. After my presentation, the Program Director of NSF, Rathindra DasGupta, stood up and applauded me for my confidence and being able to stand up on the stage and answer all the questions by the judges without any hesitation. To be honest, he really boosted up my spirit that day because after I saw the other groups present, I felt like I did a terrible job compared to everyone else.”

      WDS: “Yes, going through I2P was extremely valuable for all of us. John and I benefitted by mentoring I2P teams for all three years of the competition, and Manmeet benefitted from going through the last I2P competition. Getting familiar with the I2P judging criteria and having opportunities to make presentations and receive feedback from experts were very valuable preparations for the U. Michigan program.”

      As of this moment – have you started a new company around the business model canvas you developed at the U. Michigan I-Corps? If not – what is your short-term (1-2 year) commercialization plan – or – are you headed back to the lab to do more R&D? Are you personally continuing to work with the team?

      MS: “We started a company; however, this ATD is the first device that we wish to market through our company. The ATD is the driving force of several other product ideas that we have in mind, such as StemPATCH, which is a kit that contains the tools necessary for physicians to create a biological tissue composite to reduce adhesions and induce the natural healing process. We have already signed a contract with a leading surgical company in Europe to bring this device into the European Market first, then [in] the United States. I will be continuing my work with the ATD in addition to new and upcoming product ideas that revolve around the ATD.”

      WDS: “As part of the I-Corps Teams grant application process, our team was interviewed by I-Corps program officer Rathindra (Babu) DasGupta and U. Michigan instructors, and I was specifically asked if, as Principal Investigator, I intended to change career pathways from academic to business. My response was that I very much wanted to learn more about what it takes to advance a biotechnology product to market, but for the purpose of better helping my students, not to go into business myself. I thought that my response would jeopardize our chances of getting a grant, but the I-Corps program officer told me that that is the usual and expected response of the Principal Investigators on the I-Corps teams.”

      Was there an “a-ha” moment in your customer discovery process? Asked other ways: what was your most important, surprising or memorable “pivot” or what was the assumption you had the most difficulty letting go?

      MS: “The most shocking moment for the entire team was to realize through our interviews how much doctors are accepting of bovine thrombin use and basically narrowing it down to if the patient is able to get up off the operating table – then they’ll use the product. At that point we did not have much of a “need to have” type of product but then we learned that Europe actually banned the use of bovine products. That’s when we realized our real customers are in Europe! Forget pivoting into a new customer segment we had to pivot into a whole new, foreign market! When we learned this I did not think for a second that I would be able to go to Europe and speak to company owners and representatives themselves, one-on-one. It was the best experience of a lifetime!”

      WDS: “Before the customer discovery process, we thought that the FDA’s black-box warning on bovine thrombin would cause every user of thrombin to prefer the Autologous Thrombin Device, which makes thrombin from the patient’s own blood. A big “a-ha” moment was that, in our customer interviews, we learned that many clinicians are willing to use bovine thrombin and therefore are not motivated to change to autologous thrombin. Next “a-ha” moments were that bovine thrombin is shunned in Europe, so that autologous thrombin is of much greater interest there, and that some [medical] specialties in the U.S. also are very interested in using autologous thrombin. So, there is a market, though it’s not as big as we initially thought.”

      Do you “buy-in” to the Lean LaunchPad process for biotechnology commercialization? Why?

      WDS: “Yes, to biotechnology scientists and engineers, it makes sense to do experiments in order to develop a business model, just as we do experiments to advance our biotechnology research. Also, there’s no substitute to actually interviewing customers and others in the ecosystem.”

      For readers like you – do you have a piece of advice for other nascent academic biotech entrepreneurs?

      WDS: “As an academic, I knew that it would be extremely challenging to be on an I-Corps team and go through the I-Corps program, but I believed that I would learn the most by this “learning-by-doing.” It was very demanding, but worthwhile – I’m still processing all that I got out of the intense experience.”

      MS: “Be the leader and make the most out of your experience. You need to really think like a an entrepreneur to really understand who you need to talk to and why, and with your scientific background be able to narrow down the specific customers that you wish to target. It is easy to ask people for an interview but it is difficult to get them to actually say yes. Use all your resources, LinkedIn, Professors, research labs at your universities, etc. What I have learned is that you really need to make yourself sound and look credible. If you know enough information about your topic to have a full blown conversation…people will actually give you a chance to speak to them. Ask your interviewees if they have anyone (at least 3) individuals in their minds that they believe would be great to speak with about your product idea.”

      Anything else? Like..how many customers/experts/advisors did you interview? Who were your favorites?

      WDS: “From July 14 to August 24, 2014, our team was asked to do at least 100, preferably in-person, interviews. Each week of the course, the instructors told us that our team needed to do more to reach that number. When the 24 teams in our cohort made our final presentations at U. Michigan on August 25, 2014, each team that got to 100 interviews was applauded. We did 82 interviews and weren’t applauded. So, we were greatly surprised when the instructors gave out their only award to our team, for best embodying the I-Corps spirit. I felt very grateful that so many clinicians and others gave of their valuable time to talk with us, including specialists in orthopedic surgery, periodontics, oral surgery, podiatry, burns, veterinary medicine, perfusion, nursing, hospital procurement, international trade, and marketing. Several weeks into the course, the instructors told us that we really needed to go do interviews in Europe, so Manmeet, our Entrepreneurial Lead, did so in the Netherlands, Belgium, and France. A person in Switzerland even flew to Brussels to meet with Manmeet.”

      MS: “We interviewed a total of 86 professionals within a 5 week time period. I would have to say that I enjoyed speaking to all of my interviewees because they were all very considerate and gave out little secrets to me in order to help guide my next steps in the program which I really enjoyed…At the UC Davis Medical Center, I had the pleasure of meeting with an Orthopedic Surgeon who is doing a great deal of research himself regarding growth factors in platelet-rich plasma, Dr. Mauro M. Giordani. He was a great pleasure to speak to because he not only shared his personal thoughts about the product idea but how others feel about it, and he gave great examples of surgeries that use thrombin or platelet-rich plasma. The way he explained the details really interested me and I really wish I was able to see the procedure where they use autologous cartilage to repair damaged cartilage in real life! In Europe, I had the great pleasure of meeting with Michael Joos who is the CEO and a co-founder of the Avance Medical Groups in Geneva, Switzerland. He flew out from Geneva to Brussels, Belgium in order to meet with me and speak to me about our product idea. He had a great personality, very enthusiastic and extremely informative. Joos was the one who really told us that there is definitely a market for our product and that it will be something that the United States will approve soon as well. He was also extremely encouraging and really acknowledged me for what I have done and what I am currently doing at such a young age. I am very grateful of the opportunities that I have been given through the I2P and the National I-Corps Teams Program. These programs have truly made me way more confident and credible than I was ever before. My public speaking skills and social skills have improved to the point that I cannot tell if I am actually that same quiet individual that I used to be.”


      *Ms. Singh and Dr. Smith’s responses have been lightly edited for style and clarity.

      **One benefit of working through the CSU I-Corps Site is that teams are eligible for the NSF I-Corps Teams program, even if team members have not previously been an NSF principal investigator.

        Mapping CIRM Bridges Program Impact

        Last week a CSU team made public comments in support of the California Institute of Regenerative Medicine (CIRM) Bridges program.  The CIRM board* decided to extend the program for one year.  Of course, we’re hoping CIRM will decide to extend the program even longer.

        Along with Ephraim Smith, Jill Adler-Moore and me, Sara Downey from ViaCyte made comments. Sara is a Humboldt State University graduate.  Ms. Downey is a former CIRM Bridges Scholar who did an internship at University of California, San Francisco before landing a job at ViaCyte in San Diego. Even though Drs. Smith and Adler-Moore made important points, all ears in the room were on Ms. Downey as she made her remarks. You see, she represents the collective outcome and effectiveness of the Bridges program better than numbers and reports** can.

        In 2009 we made the case that the Bridges program would operate as a networked workforce development program. The CSU educates undergraduate and master’s students.  After they complete their degrees, they have a spectrum of career paths to follow: into industry, into medical school, into doctoral degree programs, etc.  CIRM hopes that Bridges graduates continue their interest in regenerative medicine and take their skills into positions and programs to accelerate developments in the stem cell field.  As they advance so does the field.

        In fact Sara Downey’s presence at last week’s meeting was electric because most everyone in the room knew she’s on a team developing an embryonic stem cell-derived product as a treatment for type 1 diabetes.  In fact ViaCyte announced this week they implanted their device into the first patient as part of its FDA-approved phase I/II clinical study.  No one knows how the clinical trial will work out but hopes are high that the device is safe and effective and, especially, that patients might benefit.  It was a blast talking with Sara over lunch after the meeting.*** After four years on the job, she’s transformed from a fresh biological sciences graduate with academic research experience into a biotech professional comfortable talking about Six Sigma, cGMPs, regulatory affairs, biotech business cycles, and even process engineering! My impression is that her learning curve mirrors the learning curves at CIRM as well.

        So how do you show that a workforce development program is successful and effective? If only we could get in-person updates from all 702 of our Bridges Scholars!  We did the next best thing (in a more efficient but less personal way) by asking for “last known status” data from the Bridges PIs.****  We discovered that 89% of the Bridges Scholars (n=530) find a job or enter a stem cell research-related graduate degree program within one year of their degree completion.  This is pretty convincing evidence that employers and admissions officers value our graduates’ knowledge, skills and accomplishments. For comparison, only 40% of life sciences graduates found degree-related employment during the Great Recession.  Likewise, the students themselves choose to continue in stem-cell inspired pathways, suggesting their experiences were supportive and transformative; only 6% chose to do something entirely different.  As CIRM decides on what form a Bridges 2.0 program might take, I’m sure the Bridges PIs will be investigating “what worked” and what needs improvement in each of their programs.

        Last week I really wanted to show a “last known status” map – but when you make public comments you’re lucky to get a microphone and three minutes!  I’ll share the data here. Red map markers indicate CSU campuses hosting CIRM Bridges programs. Blue map markers with flask icons indicate organizations employing Bridges graduates (dark blue = company; light blue = non-profit). Green markers with a portico icon indicate universities at which Bridges graduates are attending graduate or medical school programs. (The map is not accurate down to street level; markers indicate only approximate city vicinity!) As I dust off my *.kml skills and the Bridges PIs provide new data, I’ll work to make a more layered map with interesting data queries – but for now – click on the markers, zoom and pan (don’t forget to zoom out to get the international view).

        I am happy to see the number and diversity of companies in California hiring Bridges graduates. The roster includes not only early-stage, “next gen” California biotech companies, but also some venerable heavy weights in the pharmaceutical business. This is a healthy mix of organizations working to advance stem cell technologies. In spite of the recession and a drought of early-stage capital, California is still blessed with entrepreneurs and innovative developers choosing to work in the biomedical field. Just think what the map will be like when a few more classes of Bridges alums join the regenerative medicine efforts, additional product development investments are made, and technological challenges are worked out!

        It’s been a good month for the CSU’s researchers.  In addition to the CIRM Bridges extension, CSU campuses won Helmsley Trust-supported STEM Collaboratives grants and NIH-funded BUILD awards.  In combination these investments help us offset cuts in public funding, build inspiring and engaging, up-to-the-minute courses, and support the CSU’s faculty research mentors who make all of this possible.  Most of all these investments guarantee we’re graduating CSU students ready to make a contribution, to develop viable technologies, and to move companies and research teams forward.

        ________________

        * The CIRM board is called the Independent Citizens’ Oversight Committee, the ICOC.

        **The report (.pdf) we submitted to CIRM is linked here.

        ***She’s agreed to speak at CSUPERB’s Strategic Planning Retreat in mid-November. She not only speaks as an alum or an industry professional – but also as an employer. She supervises CIRM Bridges interns from Cal Poly San Luis Obispo at ViaCyte!

        ****Many thanks to the Bridges graduates who answer repeated surveys from the CSU and to the PIs and program administrators who collated this data together for me!

          Goosebumps

          It was a huge day for undergraduate researchers and biotechnology faculty mentors at CSU Long Beach, CSU Northridge and San Francisco State University.

          The NIH announced today that all three universities won BUILD grants. These are huge grants ($17million – $22million over 5 years). Each grant will help to prepare greater numbers of undergraduate students for biomedical research careers, to intentionally support students’ work towards their goals, and to carry out studies to gauge the effectiveness of campus programming. Because the CSU’s students – as a whole* – reflect California’s demographics, these grants are also designed to help improve the diversity of the biomedical research workforce.  Interestingly each of the three CSU BUILD programs will be studying a different angle of the cultural and institutional changes needed so that more underrepresented students persist and succeed in biomedical research-based career paths.

          BUILD programs will support undergraduate researchers on the three campuses and at partner sites – including both community organizations and research-intensive universities. We all know that mentored research experiences (faculty-mentored and peer-mentored) are high impact practices, shown to engage and inspire undergraduates.  They also happen to be exactly the kind of experiences biotechnology employers, medical schools and doctoral programs are seeking in our graduates.  So – all in all – this new investment in the CSU’s students and faculty mentors is a huge win for California (and the nation’s) biotechnology and biomedical communities!

          From left: Professor of Biology Carmen Domingo (CSUPERB PI), Professor of Cognitive Psychology Avi Ben-Zeev, Professor of Biology and Lead Investigator for SF BUILD Leticia Márquez-Magaña (CSUPERB PI) and Associate Professor of Chemistry/Biochemistry Teaster Baird Jr. Photo Credit to SFSU (http://news.sfsu.edu/sf-state-awarded-17-million-nih-enhance-workforce-diversity-biomedical-research)

          From left: Professor of Biology Carmen Domingo (CSUPERB PI), Professor of Cognitive Psychology Avi Ben-Zeev, Professor of Biology and Lead Investigator for SF BUILD Leticia Márquez-Magaña (CSUPERB PI) and Associate Professor of Chemistry/Biochemistry Teaster Baird Jr. Photo Credit to SFSU (http://news.sfsu.edu/sf-state-awarded-17-million-nih-enhance-workforce-diversity-biomedical-research)

          But the news is also tremendously exciting and personal to the CSUPERB community. The grants involve many of our friends and colleagues, CSUPERB PIs, chief research officers, Presidents’ Commission and FCG members. For years it seems we’ve been talking amongst ourselves about the strategic need for more public and private support for undergraduate education and research.  Even at the national level there has been much talk and reporting about closing achievement gaps, but relatively few dollars were targeted to undergraduate students and researchers on our campuses.  Of course – taking into account last week’s announcement of the Helmsley Trust-supported STEM Collaboratives – it’s plain to see CSU faculty and administrators are doing much more than talking about things. But now they have some new resources with which to innovate and address head-on the implicit biases in our education and research culture.  I’m just saying – tonight many of us have goosebumps!

          ____________________

          *Not our STEM graduates, however.  See data here.

           

            VISTAbuzz: The Science of Business

            It’s been a busy start-up kind of fall for the CSUPERB program office. Things keeping me in the background include: opening up this year’s poster abstract process* for the 27th Annual CSU Biotechnology Symposium, advocating for the CIRM Bridges programs, seeing Helmsley Trust awards made for new CSU STEM Collaboratives, issuing the new Requests for Proposals (RFPs) for CSUPERB grant programs, and teaching and mentoring our first class of CSU I-Corps teams.**

            How does the four-person CSUPERB program office stay on top of all this program activity?  Well – nearly one hundred faculty committee volunteers are working to move things forward with us this fall.  As examples, Paula Fischhaber (CSU Northridge) is overseeing the symposium award selection process this year and Math Cuajungco (CSU Fullerton) is organizing the Graduate School Information Session for students who attend the symposium.  But this fall the program office is extra-fortunate to have the help of two fine women – Dayna Zarate (our student assistant) and Shannon Palka (our AmeriCorps VISTA volunteer).

            Dayna handles the tsunami of submission files (poster abstracts, proposals, registrations, etc.) our office receives. She’s got a couple years of administrative experience working in our office now. I think she could run her own public health grant program and maybe she will some day! Shannon is helping us ramp up and figure out how best to interest students in CSU I-Corps opportunities. She’s also taken on most of the I-Corps team liaison activities, meaning she’s the one most teams reach out to figure out how to apply and spend microgrants, how to upload documents to the teams’ Google Drive, how to get intellectual property advice on campus, how to make contact with industry mentors, how to find appropriate biotech meetings, etc. etc. etc. (…including the @csu_icorps Twitter feed)!

            So that I can get my next CSU I-Corps webinar ready for our 10/24 meeting (multi-sided biotech markets, anyone?!), Shannon Palka is our guest blogger today. Her essay below appeared first (with more photos) on the CSU STEM VISTA blog.  Take some time to read other posts there from the STEM VISTA volunteers working on CSU university campuses statewide. Thanks to Shannon and her colleagues we serve our students and surrounding communities more effectively. As you’ll read below – these capable, thoughtful VISTA volunteers are already strategic and – dare I say – entrepreneurial leaders!

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            “The Science of Business

            As you can read about on this blog, my CSU STEM VISTA colleagues are helping provide opportunities to STEM students across the nation’s largest four-year public university system. They’re working to provide research opportunities, internships, mentoring, career prep, etc., and they’re all doing amazing things.

            My program has a slightly different flavor than the other projects you’ll read about here, because of its distinct business and entrepreneurship emphasis. I am working with student and faculty researchers to implement a program funded by the National Science Foundation (NSF) called Innovation Corps (or I-Corps). In essence, [the CSU] I-Corps is an immersive, interdisciplinary experience that trains nascent academic entrepreneurs and curious researchers about how to bring their discoveries from the lab to the market. The emphasis is learning rather than commercial success, which is pretty unique as far as entrepreneurship programs go. STEM students learn business skills and networking and develop interpersonally in a low-risk environment, adding another dimension to their undergraduate training and preparing them for life after graduation, no matter what field they intend to enter.

            Now, my undergraduate degree was in English and my professional experience is in community building. I never took a business class, and I was never tempted to. I assumed they would be about laws and regulations, how to make a spread sheet, and other topics I just do not find interesting. Maybe that assumption is right. Like bannerI said, I never took a class.

            In planning and promoting the new I-Corps program for CSU students across all 23 campuses, I had to learn about effective entrepreneurship so I could explain the benefits of I-Corps to researchers with as much business training as I have. So, I went through rapid commercialization training, similar to what we’re providing I-Corps participants. My learning curve was a sharp right angle. It was a baptism by fire, of sorts. What I learned surprised me.

            Entrepreneurship isn’t about making money – at least not intrinsically. It’s about solving problems. Step One of a successful venture is finding the biggest, baddest problems that plague people relentlessly. These are “migraine problems,images (1)” as Diana Kander dubbed them in All In Startup, because they’re the ones you would do anything to get rid of. Step Two is finding a successful, practical remedy to that problem.  It’s about crafting solutions. There’s just as much experimenting and discovery in entrepreneurship as there is in a traditional chemistry lab.

            Step Three is the kicker, and, if done right, it should color steps One and Two. Step Three is wasting no time or money in the process.

            I’ve been immersed in entrepreneurship theory, and I’ve learned there’s no shame in abandoning an idea that won’t work, or that just isn’t the best. We make assumptions about good ways to fix a problem, and – since we’re human – those assumptions are often flawed. Maybe we don’t fully understand the problem. Maybe we’re making assumptions about the needs of everyone who will be affected, or the broader context you’re working in.

            It’s not because we’re stupid. It’s because we’re human. The scope of our knowledge and understanding can fundamentally not encompass everything we’d like to know, or even everything we perhaps should know.

            So, rather than throwing away good money after bad trying to make an imperfect solution work, successful entrepreneurs strive to find any potential flaws early, fix them and change course, or abandon the idea and begin again in a new direction.

            This is the entrepreneurial spirit. It’s actively searching for the good and the bad in a plan. It’s identifying the unknown through research and persistence and adapting to the unexpected, accordingly. It’s cutting your losses before you’ve bankrupted your time and resources. It’s learning; it’s creating; and it goes hand in hand with STEM.”

            - Shannon Palka (October 20th, 2015)

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            * We received 318 abstract submissions this year from 21 CSU campuses, representing research from about 160 faculty-led labs across California.  We’re expecting we can accept about 82% of them this year.  The poster abstract selection committee is hard at work!

            **Teams should start forming for the next two CSU I-Corps classes, or cohorts!

              Why we do what we do

              There is a fun meme circulating the Twittersphere these days thanks to the NatureJobs blog.  Scientists are tweeting in answer to the blog’s prompt #IAmAScientistBecause. The answers are all over the map; my current favorite is from @mimimibe who tweets, “it sometimes made me feel like a cartoon character.” The #IAmAnEngineerBecause and #IAmAnEntrepreneurBecause hashtags haven’t really taken off yet – but maybe they will!

              Program administrators don’t have their own hashtag yet,* but there is nothing like annual reporting season to remind us why we do what we do.  At first glance annual reporting might seem like a big data gathering and excel chart-making exercise with an audit cloud over it.  But once the data are organized and normalized, the stories, exceptional accomplishments and program impacts begin to rise above the noise.

              We collect these stories to explain what CSUPERB is all about in our annual report. Stories about CSU faculty, students and alumni personalize and make real the numbers represented in those excel charts. This year’s version is linked here for your reading pleasure.

              We never have room to share all the great stories we hear from CSUPERB-supported faculty and students.  This year I purposefully asked investigators, instructors and researchers for permission to share their stories or quotes here on the blog.

              Eden_Wood_CSUN_atposter

              Shannon Wood (center) presents her research results at the 26th annual CSU Biotechnology Symposium in Santa Clara, California.

              My correspondence with Shannon Wood caught her mid-job search.  Ms. Wood worked with Dr. Sean Murray at CSU Northridge and completed a master’s degree this spring. Ms. Wood won a Spring 2014 CSUPERB travel grant to travel to Germany for an EMBO workshop titled “Stalked alpha-Proteobacteria and Relatives: From Genes to Structure.” She wrote in her final report, “…I was able to meet many of the researchers whose papers I cited in my thesis. It’s amazing how ‘real’ even the most established researchers are. I met Lucy Shapiro, one of my biggest idols; she revolutionized developmental biology research using Caulobacter crescentus…I was able to sit across from her at meals and listen to her endless stories…Needless to say, this meeting was more than I could have ever dreamed it would be.”  Ms. Wood is an exceptionally successful researcher; she was an Eden Award Finalist at the 26th CSU Biotechnology Symposium and won the Young Investigator Award at the American Society for Microbiology (ASM) meeting in May 2013.  In her final report to CSUPERB she said she thoroughly enjoys research and wants to “stick with it.” I found out this week Shannon landed a job at the USC Norris Cancer Center in August, where she’s working on the PsychENCODE project in Peggy Farnham‘s lab. My guess is she’ll be an exceptional mentor – and maybe even an idol some day – for up-and-coming students and trainees as she establishes her own research career.

              Here are some other noteworthy updates and comments from CSUPERB-supported students and faculty to help bring voices to the annual report data:

              “This CSUPERB grant was instrumental…The funding came at a critical time and I am very grateful for the support…If possible please share my appreciation with the grant reviewers.” – Andrew Voss (CSUPERB New Investigator PI, Cal Poly Pomona, now Wright State University), who made a pivotal discovery related to Huntington’s disease.

              “This program is invaluable! It is particularly important…(as) national grants are becoming more and more difficult to come by. Also, belonging to a small biology department (like the one at CSUEB) with faculty pursuing diverse research interests, faculty like me can feel isolated at times. It is difficult to stay up to date in my field when I am working in isolation and do not have access to all the latest publications. Going to these meetings helps ameliorate these issues to some degree.” – Maria Gallegos (CSUPERB Spring 2013 Travel grant, CSU East Bay), who presented lessons learned teaching a discovery-based course at the 19th International Caenorhabditis elegans Meeting.

              “This has been an incredibly valuable program for us. It has allowed us to develop critical preliminary data for grant submissions, as well as funding student research, which has helped them get into top biomedical PhD programs in the country…It has also allowed me to continue my research and earn tenure and promotion to associate professor.” – Miri Van Hoven (CSUPERB Research Development PI, San Jose State University), who was also featured in The Chronicle as a mentor to graduate students interested in transitioning to faculty positions.

              “This is a great program for New Investigators who are looking to apply for extramural funding and need key data to demonstrate that (1) their objectives and specific aims can be validated and (2) they are capable of performing these experiments in their laboratory setting…With the data gathered with the CSUPERB grant, I can now show that I have the training and resources at CSULA to execute the experimental design I propose.” – Katrina Yamazaki (CSUPERB New Investigator PI, CSU Los Angeles) who started up her lab with the help of five remarkable undergraduate and master’s students who are continuing on in biotechnology-related career paths.

              “The CSUPERB grant program is a keystone in the CSU system’s support of student training in biotechnology and molecular biology. The program not only provides research funding support for faculty to pursue innovative, and potentially transformative, avenues in biotechnology research, but it also provides the financial support needed to train students in the technologies of tomorrow.” – Sean Lema (CSUPERB New Investigator PI, Cal Poly San Luis Obispo) who obviously understands CSUPERB’s “dual strategy” of funding!

              Dr. Lema’s quote is a fitting book-end to the 2013-2014 academic year at CSUPERB. At the August Faculty Consensus Group meeting, we kicked off our strategic planning process.  We write a new strategic plan every three years.  This fall CSUPERB leadership will be pouring over annual reports, PI final reports, and feedback from our communities of interest, learning, and practice to figure out how best to serve the CSU’s biotechnology instructors, researchers and entrepreneurs.  Check back in this spring to read not only about “why we do what we do,” but also how we’ll do things 2015-2018.  My guess is that we’ll continue to invest in promising young researchers, engaging, effective curriculum and inspirational mentors across the California State University.

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              *maybe because we still self-identify as scientists, engineers or entrepreneurs!